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Tumor Expression
- Fetal mice express high levels of CCK mRNA in cardiac myocytes (112).
- The outward movement of TM6 is a hallmark of receptor activation and the various extent of the TM6 openness relative to other TMs was proposed to be the determinants of G protein subtype specificity47,48.
- The major sites of CCK expression are as mentioned endocrine cells in the gut, the brain, and in peripheral nerves.
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- For the gastrin-17–CCK2R–Gq–scFv16 complex, a total of 3,995,739 particles were automatically picked from 6611 images.
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The assays have confirmed that protein- and fat-rich food is the most important stimulus (11, 54). Of the constituents, protein and l -amino acids as well as digested fat cause significant CCK release (54, 55). Carbohydrates only release small amounts of CCK (54), but hydrochloric acid also stimulates release (55). As described earlier (9), “the exomal unit of the CCK gene is seven kilobases interrupted by two introns (23). Whereas the function of the E-box and the GC-rich region is not fully clarified (26, 27), the combined CRE/TRE sequence plays an important role in the regulation of CCK transcription.
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